Fuentes-Sánchez J, Pena-Burgos EM, Tapia-Viñe M, Pozo-Kreilinger JJ, Ortiz-Cruz EJ. Metastatic multicentric epithelioid angiosarcoma of bone. A case report with pitfalls. Tumor seeding after percutaneous biopsy and hypercalcemia. J Surg Case Rep. 2025 Jan 7;2025(1):rjae022. doi: 10.1093/jscr/rjae022. PMID: 39776833; PMCID: PMC11705994.
Angiosarcomas are a type of malignant tumor of vascular origin. They represent <1% of all primary bone tumors. The multicentric or metastatic does not differ in its high aggressiveness and poor prognosis. A 72-year-old male with bone angiosarcoma initially located in proximal femur. After biopsy in a non-expert sarcoma center, he presented tumor involvement in the needle trajectory and multicentric/metastatic involvement at the sacro-coccygeal level. He associated tumoral-hypercalcemia and was referred to our sarcoma center. He was treated by tumoral resection and tumor prosthesis. In the follow-up he presented pulmonary metastasis and new implants, dying 2 months later. Multicentric or metastatic bone involvement in angiosarcomas has only theoretical relevance for their management. Biopsy should be performed in sarcoma centers due to the risk of dissemination. Although hypercalcemia in sarcomas is uncommon, we highlight its investigation.
Metastatic multicentric epithelioid angiosarcoma bone Journal of Surgical Case Reports, 2025,
