Pozo-Kreilinger JJ, Pena-Burgos EM, Ortiz-Cruz EJ, Cordero-García JM, Barrientos Ruiz I, Tapia-Viñe M, Peleteiro-Pensado M, Bernabéu-Taboada D. Primary intraosseous papillary intralymphatic angioendothelioma of the distal femoral epiphysis: a case report with literature review. Skeletal Radiol. 2024 Apr 15. doi: 10.1007/s00256-024-04674-8. Epub ahead of print. PMID: 38619614
Papillary intralymphatic angioendothelioma (PILA) is an exceptionally rare metastasizing soft tissue tumor. It tends to arise in the subcutaneous tissues of distal extremities in children. Only four intraosseous PILA cases have been reported until now in English language literatur
We present a case of PILA arising in the distal femoral epiphysis of a 50-year-old female patient.
Primary intraosseous PILAs are exceedingly rare tumors that should be considered in the differential diagnosis of vascular bone tumors.
Organization (WHO) tumor classification, they are considered an intermediate (rarely metastasizing) neoplasm (Fanburg-Smith J. Papillary intralymphatic angioendothelioma. In: WHO classification of tumours of soft tissue and bone. 5th. Agency for Research on Cancer; 2020:161–162) The majority are located in subcutaneous tissue,although a few cases have arisen in deeper locations such as the tongue, spleeN, testi, or atrium. Only four cases have been reported in bone
